Enter Sikeston from I-55 at Exits 66 or 67.

From I-55, Exit 66 - Go west to US 61, then north on US 61 (South Main Street) to US 62 (Malone Avenue - Montgomery Bank will be on your left). Turn Left (West) on Malone Avenue and continue through 1 traffic light then turn right and park at the Red Caboose.

From I-55, Exit 67 - Go west US 62 (Malone Avenue) through several traffic lights to US 61 (Main Street) - (Montgomery Bank will be on your left). Continue West on Malone Avenue through 1 more traffic light then turn right and park at the Red Caboose.

A more detailed map of the Depot Museum in the Downtown Sikeston area is shown below.