The Upper Gallery: Enjoy permanent historical exhibits of the Mississippian Indians tribes, "Swampeast Missouri" and our cotton growing heritage.
The Art Gallery: A wide variety of artistic styles from local and regional artist. The display change every two months, and often are available for purchase.
The Main Gallery: This the largest display hall in The Depot, and combines history, art and special exhibits. Permanent displays include : The Parlor, The history of Parks Air Base, and the invention of the mechanical horse.
The Sikeston Room: This room is dedicated to the history of Sikeston as shown through pictues, films and artifacts.